Macrocyclic derivatives of 6-methyluracil: New ligands of the peripheral anionic site of acetylcholinesterase
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چکیده
منابع مشابه
Macrocyclic derivatives of 6-methyluracil: New ligands of the peripheral anionic site of acetylcholinesterase.
BACKGROUND Acetylcholinesterase (AChE) inhibitors are widely used in medicine for pharmacological correction of cholinergic neurotransmission pathologies such as myasthenia gravis (MG) and Alzheimer's disease [1, 2]. The efficacy of anti-AChE drugs is based on their ability to potentiate the effects of acetylcholine (ACh) due to a decrease in the rate of AChE-catalyzed hydrolysis of ACh. Crysta...
متن کاملMacrocyclic derivatives of 6-methyluracil as ligands of the peripheral anionic site of acetylcholinesterase
A. E. Arbuzov Institute of Organic and Ph 420088, Russia. E-mail: [email protected]; Fax: + N. M. Emanuel Institute of Biochemical Ph M. V. Lomonosov Moscow State University, Kazan Institute of Biochemistry and Biophy Kazan Federal University, Kazan 420000, R Kazan State Medical University, Kazan 420 DYNAMOP, Institut de Biologie Structurale † Electronic supplementary information analytical data and ...
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ژورنال
عنوان ژورنال: International Journal of Risk & Safety in Medicine
سال: 2015
ISSN: 0924-6479,1878-6847
DOI: 10.3233/jrs-150695